citizen of humanity
Public Citizen Names Two Groups For Whom Fosamax Has No Benefit of Therapy
Bone-strengthening medication Fosamax became one of the bestselling drugs in the United States and the rest of North America due to the millions of people taking this drug for osteoporosis. However, the use of this bisphosphonate entails serious adverse effects, including osteonecrosis of the jaw. But before anything else, let's have a deeper look on this severe dental condition called osteonecrosis of the jaw.
In a recent food and drug Administration (FDA) conference, the issue about doctors prescribing bisphosphonates indiscriminately was also addressed. Consumer support group Public Citizen mentioned two groups who are not getting any benefits from treatment. These populations who may be unnecessarily taking the drug are also putting themselves at risk of this jaw bone problem.
Osteonecrosis of the jaw, which is commonly known as ONJ or “dead jaw,” pertains a dental condition where a portion of the jawbone protrudes above the gums. This bone tissue does not receive enough blood supply, which eventually leads to the its death or necrosis. The terms “Bis-Phossy Jaw” and BON are invented by scientists who refer to ONJ as having been brought by the use of bisphosphonates, such as Fosamax.
During the early stage of ONJ, patient would appear to have no symptoms until the disease develops, in which one could feel pain, swelling and redness usually associated with gum infection. A trademark for ONJ is the (visible exposure of) bone tissue which may last for more than eight weeks. Additionally, the condition may be worsened by dental procedures like tooth extraction.
ONJ is generally treated with non-surgical approach consisting of antimicrobial rinses, systemic antibiotics, systemic or topical antifungal treatment and pain relievers. In later stages, treatment might require surgical debridement or resection in conjunction with other nonsurgical treatment. It is imperative to inform the dentist if one is on a bisphosphonate treatment before any surgical intervention – no matter how minor - is carried out
In July 2005, Merck changed the label of Fosamax regarding ONJ risk as ordered by FDA. Nonetheless, several long-term Fosamax patronizers claimed that Merck lacked proper disclosure of the said risk causing them to agonize such side effect and other backlash. This moved affected men and women to file Fosamax lawsuit against the pharmaceutical company.
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