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Public Citizen Names Two Groups For Whom Fosamax Has No Benefit of Therapy
Because millions of Americans are afflicted with osteoporosis, bone-strengthening drug Fosamax has been considered one of the bestselling drugs in the United States and North America. However, the use of this bisphosphonate entails serious adverse effects, including osteonecrosis of the jaw. Now, what is osteonecrosis of the jaw and what everyone needs to know about this serious dental condition?
In a recent food and drug Administration (FDA) conference, the issue about doctors prescribing bisphosphonates indiscriminately was also addressed. Consumer support group Public Citizen mentioned two groups who are not getting any benefits from treatment. These groups may only be putting themselves at risk of developing this jaw bone disease unnecessarily.
Osteonecrosis of the jaw, also known as ONJ and "dead jaw," is a condition in which an area of the jawbone is exposed. It usually occurs when part of the bone does not get enough blood supply, leading to the death of the bone tissue. Scientists have coined terns such as “Bis-phossy Jaw” and BON to describe bisphosphonate-related ONJ.
In the early stage, the disease is often asymptomatic, but as it progresses, patient would feel pain, swelling and redness related to an infection on the gums. A trademark for ONJ is the (visible exposure of) bone tissue which may last for more than eight weeks. Moreover, dental procedures like tooth extraction could aggravate the condition.
ONJ is generally treated with non-surgical approach consisting of antimicrobial rinses, systemic antibiotics, systemic or topical antifungal treatment and pain relievers. When advanced stages are reached, surgical debridement or resection, together with nonsurgical interventions, might be performed. It is imperative to inform the dentist if one is on a bisphosphonate treatment before any surgical intervention – no matter how minor - is carried out
In July 2005, Merck changed the label of Fosamax regarding ONJ risk as ordered by FDA. Yet, some Fosamax patients, who are using the drug for a long time, believed that Merck did not properly warned its patients, causing them to deal with the side effects and other drug backlash. Consequently the affected parties initiated the filing of Fosamax lawsuit against the maker of the drug.
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